Scrapping excessive neural connection helps build new connections

Researchers found that neural activity that retracts excessive early innervation in a certain pathway helps make late neural connections in a different pathway. This may provide a self-organizing mechanism of neural connections, and additionally, early excessive innervation may serve as a guide for making late neural connections.

The formation and refinement of neural networks is known to be often an activity-dependent process, but mechanisms and nature of activity are not yet clearly understood.

During neuronal circuit formation, afferent…

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